College Basketball Picks Against the Spread: Big South Games Today, February 22

Published 8:57 pm Friday, February 21, 2025

The High Point Panthers versus the Gardner-Webb Runnin’ Bulldogs is a game to watch on the Saturday Big South college basketball slate that includes a lot of competitive contests. For all our predictions against the spread, scroll down.

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Big South Picks ATS Today

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Pick: Charleston Southern -7.5 vs. South Carolina Upstate

  • Matchup: South Carolina Upstate Spartans at Charleston Southern Buccaneers
  • Projected Favorite & Spread: Charleston Southern by 7.8 points (Bet on BetMGM)
  • Spread: Charleston Southern -7.5
  • Time: 2 p.m. ET
  • Date: February 22
  • TV Channel: ESPN+
  • Live Stream: ESPN+

Bet on this or any men’s college basketball matchup at BetMGM.

Pick: High Point -6.5 vs. Gardner-Webb

  • Matchup: High Point Panthers at Gardner-Webb Runnin’ Bulldogs
  • Projected Favorite & Spread: High Point by 7.1 points (Bet on BetMGM)
  • Spread: High Point -6.5
  • Time: 2 p.m. ET
  • Date: February 22
  • TV Channel: ESPN+
  • Live Stream: ESPN+

Bet on this or any men’s college basketball matchup at BetMGM.

Pick: Radford -6.5 vs. Presbyterian

  • Matchup: Presbyterian Blue Hose at Radford Highlanders
  • Projected Favorite & Spread: Radford by 6.5 points (Bet on BetMGM)
  • Spread: Radford -6.5
  • Time: 4:30 p.m. ET
  • Date: February 22
  • TV Channel: ESPN+
  • Live Stream: ESPN+

Bet on this or any men’s college basketball matchup at BetMGM.

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