BATON ROUGE, La. (AP) — Tua Tagovailoa threw two touchdown passes and ran 44 yards for a score in his toughest test this season, Alabama’s defense stifled No. 4 LSU, and the top-ranked Crimson Tide remained unbeaten with a 29-0 victory Saturday night.

Tagovailoa took the field wearing a brace on right knee, threw his first interception of the season late in the first half and also played into the fourth quarter for the first time this season. None of those developments proved consequential. He was 25-of-42 passing for 295 yards and moved as well as well as he needed to, particularly when he sprinted up the middle of the field or his long TD run in the third quarter to give Alabama (9-0, 6-0 SEC, No. 1 CFP) a 22-0 lead.

Tagovailoa limped off the field after that play, went into the medical tent for some treatment and rode a stationary bike on the sideline, but returned for the next series.

LSU (7-2, 4-2, No. 3 CFP) entered a chance to control of the SEC Western Division with a victory, but that began to decreasingly realistic with every possession.

NO. 2 CLEMSON 77, LOUISVILLE 16

CLEMSON, S.C. (AP) — Travis Etienne ran for 153 yards and two touchdowns and 350-pound defensive tackle Dexter Lawrence added a 2-yard scoring burst for Clemson.

The Tigers (6-0 Atlantic Coast Conference, No. 2 CFP) improved to 9-0 for the third time in four seasons and can wrap up their fourth ACC Atlantic Division title next week at Boston College.

Trevor Lawrence threw a pair of early touchdown passes. Etienne went over the 1,000-yard rushing mark and scored his ACC-leading 15th touchdown. Tavien Feaster added 101 yards rushing.

NO. 3 NOTRE DAME 31, NORTHWESTERN 21

EVANSTON, Ill. (AP) — Ian Book threw for threw two touchdown passes and ran 23 yards for a score in the closing minutes to lead Notre Dame.

The Fighting Irish (9-0, No. 4 CFP) remained in line for a playoff spot and continued to build on their best start since the 2012 team went undefeated before losing to Alabama in the BCS championship game. The Wildcats (5-4) had won four in a row to grab the Big Ten West lead and they stayed in this one when it looked like Notre Dame was ready to pull away.

NO. 5 MICHIGAN 42, NO. 14 PENN STATE 7

ANN ARBOR, Mich. (AP) — Shea Patterson accounted for three touchdowns and Michigan put together a dominant performance on defense.

The Wolverines (8-1, 6-0 Big Ten, No. 5 CFP) moved a step closer toward their goals of winning a conference championship for the first time since 2004 and earning their first spot in the College Football Playoff. The Nittany Lions (6-3, 3-3, No. 14 CFP) scored with 1:59 left, avoiding getting shut out for the first time since 2001 against Michigan.

NO. 6 GEORGIA 34, NO. 11 KENTUCKY 17

LEXINGTON, Ky. (AP) — D’Andre Swift ran for a career-high 156 yards and two touchdowns on 16 carries against Kentucky’s vaunted defense and Georgia wrapped up its second straight Southeastern Conference Eastern Division title.

Swift had an 83-yard breakaway in the third quarter that gave Georgia (8-1, 6-1, No. 6 College Football Playoff) a 28-3 lead. He also had a nifty 20-yard scoring run in the second period when the game was close. Elijah Holyfield ran for a career-high 115 yards on 18 carries, scoring on a 4-yarder in the third quarter.

NO. 8 OHIO STATE 36, NEBRASKA 31

COLUMBUS, Ohio (AP) — J.K. Dobbins ran for three touchdowns and Dwayne Haskins Jr. passed for two more scores to help Ohio State beat Nebraska.

After Nebraska quarterback Adrian Martinez threw a 17-yard touchdown pass to JD Spielman to pull within five with 3 minutes left, Dobbins pounded away for two first downs to run out the clock.

NO. 22 SYRACUSE 41, WAKE FOREST 24

WINSTON-SALEM (AP) — Eric Dungey rushed for 119 yards and a touchdown, Jarveon Howard ran for two scores and Syracuse beat Wake Forest.

Dungey — whose average of 294.1 total yards per game ranks second in the ACC — was 23 of 35 for 157 yards and also ran for a 26-yard score to help the Orange (7-2, 4-2, No. 19 CFP) win their first game as a Top 25 team since the Dwight Freeney days in 2001.

GA. TECH 38, UNC 28

CHAPEL HILL (AP) — Tobias Oliver got his chance and ran with it.

Oliver rushed for 120 yards and two touchdowns and passed for a score to help Georgia Tech beat North Carolina 38-28 on Saturday.

Oliver broke a 28-28 tie with a 1-yard touchdown run with three minutes remaining for the Yellow Jackets (5-4, 3-3 Atlantic Coast Conference), who won for the fourth time in five games.

North Carolina (1-7, 1-5) had a chance to answer, but Anree Saint-Amour intercepted Nathan Elliott’s pass with 2:44 left to set up Georgia Tech’s game-clinching field goal.

DUKE 20, MIAMI 12

MIAMI GARDENS, Fla. (AP) — This time, Duke didn’t lose on a Miami miracle.

Quentin Harris’ jump pass to Daniel Helm late in the third quarter put Duke ahead for good, and the Blue Devils got a stop on the final play to beat reeling Miami 20-12 on a rain-soaked Saturday night and hand the Hurricanes their third straight loss.

Duke outscored the Hurricanes 13-0 after halftime, and won at Miami for the first time since 1976.

APP STATE 23, COASTAL 7

CONWAY, S.C. (AP) — Darrynton Evans ran for 159 yards and a touchdown as Appalachian State beat Coastal Carolina 23-7 on Saturday night.

Evans scored on a 26-yard run early in the first quarter and his 39-yard run helped set up Marcus Williams Jr.’s 1-yard score midway through the fourth. Evans entered as the second leading rusher in the Sun Belt Conference averaging 105 yards a game. Williams had 103 yards on 19 carries.

Jacob Huesman threw a 33-yard touchdown pass to Corey Xavier Sutton in the second quarter for Appalachian State (6-2, 4-1). Huesman was 9-of-19 passing for 127 yards.

Derambez Drinkard intercepted Huesman twice, including a 60-yard pick-6 in the first quarter for Coastal Carolina’s (5-4, 2-3) only score.

Appalachian State played for the first time at Coastal Carolina and leads the series 5-0.